Use of platelet-rich plasma to enhance wound healing after cesarean section: a systematic review and meta-analysis of randomized controlled trials

Cesarean section (CS) is among the most commonly performed surgical procedures worldwide, yet postoperative wound complications remain prevalent. Platelet-rich plasma (PRP), a blood-derived concentrate rich in growth factors, may enhance tissue repair, but its efficacy in CS remains uncertain. This systematic review and meta-analysis evaluated the effectiveness of intraoperative PRP injection in improving wound healing, scar quality, and pain following CS. We searched PubMed, Scopus, Cochrane Library, and Web of Science through August 2026 for randomized controlled trials (RCTs) comparing intraoperative PRP with standard care or placebo in women undergoing CS. Seven RCTs comprising 706 participants were included. Wound healing was assessed using the REEDA (Redness, Edema, Ecchymosis, Discharge, Approximation) scale, scar quality using the Vancouver Scar Scale (VSS) between postoperative day 30 and week 8, and pain using the Visual Analog Scale (VAS). PRP injection was associated with significantly improved wound healing (MD − 0.66, 95% CI − 0.74 to −0.58; p < .001), better scar quality (MD − 0.91, 95% CI − 1.37 to −0.45; p < .001), and reduced postoperative pain (MD − 1.12, 95% CI − 1.70 to −0.55; p < .001). Intraoperative PRP injection may be a promising adjunct for enhancing recovery after CS, though further large, standardized trials are warranted.