Over-the-counter turnover of antibacterial drugs and the problem of antibiotic resistance

Introduction. Over the past decades, the study of the problem of bacterial resistance to antibiotics has been steadily growing and is currently one of the most actively developing fields of science. The main driving force pushing research in this direction is the assumption of the need for an urgent solution to a potentially catastrophic problem for human health. The purpose of the study. The purpose of this review is to critically analyze modern approaches to regulating the turnover of antibacterial drugs in the context of the global problem of antibiotic resistance. To achieve this goal, the following tasks were set: 1) to systematize data on the epidemiological and socio-economic burden of antibiotic resistance; 2) to analyze modern concepts of resistance prevention, including international experience; 3) to assess the role of pharmaceutical workers in the system of control over the turnover of antibiotics; 4) formulate practical recommendations for improving the accounting system for antibacterial drugs. Material and methods. This review is performed using the method of systematic analysis of scientific literature. The search for sources was carried out in the databases PubMed, Scopus, Web of Science, eLibrary for the period 2015-2024 by keywords: antibiotic resistance, antimicrobial stewardship, over-the-counter antibiotics, prescription control. Inclusion criteria: original studies, systematic reviews, and meta-analyses on the problem of antibiotic resistance and regulation of the turnover of antibacterial drugs. Exclusion criteria: publications in languages other than Russian and English; conference abstracts without full-text versions.