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α-Methylenecamphor and α-methyleneisophorone derivatives were synthesized and their antibacterial activity on Escherichia coli was examined. α-Methylenated camphor and isophorone derivatives showed stronger antibacterial activity than the compounds before α-methylenation, as anticipated. Data of the electronic parameters of the absolute electronegativity (χ), the quantity of electron transfer (ΔΝ) and the stabilization energy (ΔΕ) with cysteine strongly supported this finding.
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Tonari et al. (2002) studied this question.
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