Key result
Elevated initial IL-10 is linked to ~4% higher 2-month mortality in acute myocarditis.
Why the study?
The disease course of acute myocarditis has a wide spectrum and predictors of short-term prognosis, including the predictive values of serum IL-10 and IL-12 levels, had not yet been established.
Do initial serum levels of IL-10 and IL-12 predict short-term mortality in patients with acute active myocarditis?
Cohort (n=24)
Do initial serum levels of IL-10 and IL-12 predict short-term mortality in patients with acute active myocarditis?
Initial serum elevation of IL-10 (≥7.0 pg/ml) and IL-12 serves as a prognostic biomarker for short-term mortality in patients presenting with acute myocarditis.
Answers are grounded in this paper and cite their sources.
IL-10 elevation may flag higher short-term mortality risk in acute myocarditis; leaves open whether cytokine profiling refines risk stratification in larger cohorts.
The disease course of acute myocarditis has a wide spectrum and the predictors of the prognosis in patients with acute myocarditis have not yet been established. In the pathogenesis of myocarditis, the cytokine environment is important. In this study, we examined the predictive values of serum levels of interleukin-10 (IL-10) and IL-12 in the short-term prognosis of patients with acute myocarditis. Twenty-four consecutive patients who had been diagnosed as having acute active myocarditis were analyzed and monitored for 2 months. The patients with myocarditis were divided into the survival group (n=16) and the non-survival group (n=8). Initial serum levels of IL-10 (P=0.0015) and IL-12 (P=0.012) in the non-survival group were significantly higher than those of the survival group, and there was a significant correlation between IL-10 and IL-12 levels (P<0.0001). The univariate analyses showed that increased serum levels of IL-10 (hazard ratio 1.041, P=0.0004) and IL-12 (hazard ratio 1.128, P=0.0346) were significant predictors of mortality. In the Kaplan-Meier analysis, high levels of IL-10 (>or=7.0 pg/ml) (P=0.0239) strongly predicted high mortality. In conclusion, the elevation in serum IL-10 levels at the initial phase appeared to predict poor short-term prognosis in patients with acute myocarditis.
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Fuse et al. (2004) conducted a cohort in Acute active myocarditis (n=24). Initial serum interleukin-10 (IL-10) and interleukin-12 (IL-12) levels vs. Survival group (n=16) vs non-survival group (n=8); IL-10 <7.0 pg/ml vs ≥7.0 pg/ml was evaluated on Short-term mortality (at 2 months) (HR 1.041, p=0.0004). Elevated initial serum IL-10 levels significantly predicted 2-month mortality in acute myocarditis (HR 1.041, P=0.0004), with levels ≥7.0 pg/ml strongly associated with high mortality (P=0.0239).
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