Quasi‐Continuous Multimodal Sensing of Urinary Oxalate Dynamics for Home‐Based Metabolic Monitoring

Continuous at-home monitoring of urinary oxalate dynamics is vital for the comprehensive management of hyperoxaluria and thus reduces the risk of kidney stone formation. However, home-based devices for capturing dynamic oxalate profiles remain elusive, as urine is challenging to sample and unstable for subsequent biochemical testing. Here we report a remote multimodal sensing platform for achieving such urine monitoring during daily sequential urination through seamless embedding into a standard urine collection bucket. This platform integrates electrochemical oxalate sensing with simultaneous pH and urine-volume measurements to correct the matrix drift in oxalate quantification. We achieve quasi-continuous monitoring of 24 h urinary physicochemical dynamics under diet-induced transient hyperoxaluria. By decoupling oxalate concentration from multimodal signals per urination, we reveal distinct metabolic response profiles under different dietary oxalate loads, providing new real-time insights into oxalate metabolism and its associated risk of kidney stones. Our all-in-one sampling-and-testing platform could revolutionize clinical urine analysis for hyperoxaluria, shifting from a one-time, multi-day turnaround assay into a paradigm of quasi-continuous monitoring with immediate feedback. This work represents a practical route toward personalized management of hyperoxaluria and a decentralized metabolic monitoring strategy for urology.