Long-Term Results of Pseudophakic Dysphotopsia with Two Different Intraocular Lenses

Background and Objectives: Pseudophakic dysphotopsia is a common cause of dissatisfaction after uncomplicated cataract surgery. We compared its course with two intraocular lenses (IOLs). Materials and Methods: In this prospective, non-randomized study, 348 of 488 enrolled patients completed two years of follow-up after implantation of the Akreos Adapt AO (n = 176) or AcrySof IQ (n = 172) IOL through a superior or temporal corneal incision. Positive and negative dysphotopsia were assessed with a modified Radford questionnaire at one wweek, eight weeks, one year, and two years. Repeated measurements were analyzed with exact McNemar tests and generalized estimating equations adjusted for incision site, age, and sex. Results: At one week, dysphotopsia was reported by 45.9% of patients with the AcrySof IQ and 21.0% with the Akreos Adapt AO (adjusted odds ratio 3.27, 95% CI 2.02–5.29); negative dysphotopsia occurred only with the AcrySof IQ (8.7%). Later differences in any dysphotopsia were small and non-significant (0.9–2.2 percentage points). Dysphotopsia decreased significantly in both groups from 33.3% to 14.7% overall. Incision site was not associated with dysphotopsia. Conclusions: Early dysphotopsia was more frequent with the AcrySof IQ, although this represents an association rather than proof of causality; with both IOLs, symptoms became less frequent over time, and annoying symptoms became rare.