Validation of the PREVENT-HF Risk Prediction Equation in US Veterans

Rebecca Lauren Tisdale; Neil M. Kalwani; Jun Fan; Valerie F. McDonald; Evan Foster Shalen; Brian L. Chan; Aradhana Verma; Natasha Din; Anju P. Sahay; Andrew P. Ambrosy; Paul A. Heidenreich; Alexander T. Sandhu

doi:10.1161/circulationaha.126.081422

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PHARM-HF 2Heart FailureCirculation

Validation of the PREVENT-HF Risk Prediction Equation in US Veterans

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What happened

Primary care pharmacist nudges are being evaluated to optimize heart failure therapy in US Veterans.

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Why the trial, key points, tables, limitations, PICO, abstract, media & sources

Why the trial?

Does education and feedback and referral nudges improve heart failure medication optimization in primary care pharmacists in the Veterans Affairs Healthcare System?

Key Points

To assess the validation of the PREVENT-HF risk prediction equation and evaluate interventions aimed at optimizing heart failure guideline-directed medical therapy among primary care pharmacists.
Study design (PHARM-HF 2 Trial) conducted across primary care clinics in the US Veterans Affairs Healthcare System.
Assessed an intervention consisting of provider education, audit and feedback, and electronic referral nudges targeted to primary care pharmacists.
Findings were presented as a late-breaking clinical trial at the American Heart Association Scientific Sessions 2026.
Primary endpoint outcomes and definitive effect estimates remain pending formal publication.

Structured PICO

Does education and feedback and referral nudges improve heart failure medication optimization in primary care pharmacists in the Veterans Affairs Healthcare System?

Population

Primary care pharmacists in the Veterans Affairs Healthcare System (US Veterans)

Intervention

Education and feedback and referral nudges

Outcome

Heart failure medication optimization

Implication

Pharmacist nudges and risk tools merit testing for HF GDMT optimization in veterans; leaves open definitive impact pending full publication.

Abstract

Randomized Evaluation of Education and Feedback and Referral Nudges to Increase Heart Failure Medication Optimization Among Primary Care Pharmacists in the Veterans Affairs Healthcare System (PHARM-HF 2 Trial). Presented by Alexander Sandhu (University of California Los Angeles, USA). Session: FS.10. Late-breaking trial at AHA Scientific Sessions 2026. Results pending.

Cite This Study

Tisdale et al. (2026) studied this question. Education, feedback, and referral nudges for primary care pharmacists are being evaluated for heart failure medication optimization in US Veterans, with trial results currently pending.

synapsesocial.com/papers/6aeca9cbbf0cce6e83e4c802 https://doi.org/10.1161/circulationaha.126.081422

Validation of the PREVENT-HF Risk Prediction Equation in US Veterans

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Full evidence

Why the trial?

Key Points

Structured PICO

Implication

Abstract

Cite This Study

Validation of the PREVENT-HF Risk Prediction Equation in US Veterans

Discussion

Member takes

Full evidence

Why the trial?

Key Points

Structured PICO

Implication

Abstract

Cite This Study

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