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BACKGROUNDRecent evidence indicates that malignant ascites may be associated with the high malignancy and poor prognosis of gastric cancer (GC) with peritoneal metastasis (PM), but no robust consensus has been reached until now. AIMTo evaluate the prognostic significance of malignant ascites in GC patients with PM. METHODSTwo independent authors conducted database searches.The searches were performed in the EMBASE, PubMed, and Cochrane Library databases, and the terms used to search included stomach neoplasms, GC, ascites, peritoneal effusion, survival, and survival analysis.Outcomes included overall survival and hazard ratios with 95% confidence intervals (CIs).Three pairs of comparisons for measuring survival were made: (1) Patients with ascites vs those without ascites;(2) Patients with massive ascites vs those with mild to moderate ascites; and (3) Patients with massive ascites vs those with no to moderate ascites. RESULTS
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Zheng et al. (2019) studied this question.
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