Bile Acids and Lipid Metabolism. I. Stimulation of Bile Lipid Excretion by Various Bile Acids

An increased excretion of biliary free cholesterol and phospholipid was shown to be produced by infusion of various bile acids into the isolated perfused rat liver system. The derivatives studied were the sodium salts of taurocholic, glycocholic, chenodeoxycholic, deoxycholic, lithocholic, hyodeoxycholic, and dehydrocholic acids. Hence, the major bile acids, normally found in the enterohepatic circulation of the rat, can exert stimulatory effects on bile lipid excretion.