Key result
Flaxseed diet lowers baseline systolic blood pressure and prevents stress-induced hypertension compared to control.
Why the study?
The effect of an omega-3-rich flaxseed diet administered during different developmental periods on the blood pressure of rats submitted to stress required investigation.
Does a flaxseed diet during different developmental periods reduce blood pressure in rats submitted to stress?
Does a flaxseed diet during different developmental periods reduce blood pressure in rats submitted to stress?
A dietary omega-3 source from flaxseed attenuates stress-induced blood pressure elevation and lowers corticosterone levels in rats, particularly when provided during gestation and lactation.
Answers are grounded in this paper and cite their sources.
Flaxseed may attenuate stress-induced blood pressure rises in rats; leaves open human translation and requires clinical trials.
OBJECTIVE: This study aimed to investigate a flaxseed diet during different developmental periods, and its effect on the blood pressure of rats submitted to stress. METHODS: ), were divided into seven groups (n = 8): flaxseed group (FG); flaxseed group gestation and lactation (FG-GL); flaxseed group weaning (FG-W); flaxseed group weaning and stress (FG-WS); flaxseed group stress (FG-S); flaxseed group gestation lactation and weaning (FG-GLW), and control Group (CG). Stress protocol was undertaken for 1 month. Blood pressure was analysed before and after the stress protocol. The left adrenal glands and serum corticosterone levels were analysed. RESULTS: Systolic blood pressure before stress was lower in all groups with flaxseed diet compared with the CG (p = .00001). After stress, CG showed higher blood pressure compared with FG, FG-GL, and FG-GLW (p = .004). The levels of corticosterone were lower in the FG between all groups (p < .000001) and the CG showed higher compared with FG-W, FG-WS, FG-GL, and FG-GLW (p < .0001). The adrenal gland did not show differences. CONCLUSIONS: Results suggest a possible factor from a flaxseed diet against the effects of stress on a blood pressure in all periods of life but especially in the gestation and lactation periods.
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Meneses et al. (2017) studied Stress-induced blood pressure changes in rats (n=56). Flaxseed diet (omega-3 source) vs. Control group (CG) was evaluated on Systolic blood pressure before and after stress protocol (p=0.004). A flaxseed diet resulted in lower systolic blood pressure before stress and prevented higher blood pressure after stress vs control.
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