Follicular Mucinosis of the Eyebrow as a Cutaneous Clue to Classic Hodgkin Lymphoma: A Case Report

Follicular mucinosis is an uncommon cutaneous reaction pattern characterized by mucin accumulation within the follicular epithelium, primarily in the outer root sheath.It may occur as a primary condition or in association with inflammatory, infectious, and neoplastic diseases.We report the case of a 26-year-old man who presented with a hypopigmented, infiltrated, pseudoalopecic plaque involving the right eyebrow, accompanied by cervical lymphadenopathy and weight loss.A skin biopsy demonstrated mucin deposition within the follicular epithelium, confirmed by Alcian blue staining.Given the associated systemic findings, a lymph node biopsy was performed and established the diagnosis of classic Hodgkin lymphoma, nodular sclerosis subtype.The patient received chemotherapy with the doxorubicin, bleomycin, vinblastine, and dacarbazine regimen and achieved a complete metabolic response on positron emission tomography/computed tomography, accompanied by resolution of the cutaneous lesion and regrowth of the eyebrow hair.This case illustrates that follicular mucinosis may provide a cutaneous clue to an underlying lymphoproliferative disorder and highlights the importance of systemic evaluation when it occurs in association with lymphadenopathy or constitutional symptoms.