Adherence to the mediterranean-DASH intervention for neurodegenerative delay (MIND) diet and its association with mental health: an updated systematic review

Background Mental health has become a major public health concern, with mental disorders accounting for a substantial proportion of the disease burden across populations. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet was developed to support cognitive function and reduce the risk of dementia. This dietary pattern combines elements of the DASH and Mediterranean diets, with a particular emphasis on food components with potential neuroprotective properties. Methods This study systematically reviewed the existing literature to investigate the association between adherence to the MIND diet and mental health outcomes. The Scopus, PubMed, and Web of Science databases were searched from inception through September 2026. Ultimately, 21 studies were included in the review. Results Findings from five cross-sectional and six cohort studies suggested that adherence to the MIND diet was associated with a reduced risk of depression. Additionally, two randomized controlled trials (RCTs) found that the MIND diet could reduce depressive symptoms. One case-control study, two cross-sectional studies, and three cohort studies reported an association between adherence to the MIND diet and reduced anxiety. Furthermore, three RCTs reported a beneficial effect of the MIND diet on anxiety. Regarding stress, only two of five cross-sectional studies and one of two cohort studies found an inverse association between adherence to the MIND diet and stress. Additionally, the two RCTs investigating this outcome did not demonstrate a beneficial effect. Conclusions Given the potential role of diet in the prevention of psychological disorders, further large-scale studies are needed to better understand the relationship between dietary patterns and mental health.