Key result
Elevated hs-CRP in type 2 diabetes is linked to ~14-fold higher odds of central obesity.
Why the study?
Patients with type II diabetes mellitus have modifiable risk factors including obesity and elevated blood pressure, while serum hs-CRP serves as a reliable indicator of coronary heart disease and CVD. Identifying possible risks in these patients warranted observing measures of obesity and blood pressure in relation to serum hs-CRP.
Observational (n=126)
No
In Bangladeshi patients with type II diabetes mellitus, both obesity (especially central obesity) and elevated blood pressure are strongly associated and positively correlated with elevated serum hs-CRP levels, underscoring the link between modifiable cardiometabolic risk factors and systemic vascular inflammation.
Answers are grounded in this paper and cite their sources.
May indicate higher cardiometabolic burden in type 2 diabetes; leaves open whether hs-CRP improves risk prediction.
Background: The patients with type II diabetes mellitus have modifiable risk factors, including obesity and elevated blood pressure. A reliable indicator of coronary heart disease, CVD in type II diabetes is serum hs-CRP, a marker of persistent low grade inflammation. The necessity to identify possible risks in these patients is of the utmost importance. The study was undertaken to observe the measures of obesity and blood pressure in relation to serum hs-CRP in type II DM. Materials and Methods: An observational study was carried out from January 2016 to December 2016 in the Outpatient Department of Endocrinology and Department of Biochemistry, Chittagong Medical College. By using non-probability consecutive sampling, total 126 participants with type II DM were enrolled in this study. BMI was calculated, and waist circumference was measured to determine central obesity. Plasma glucose and serum hs-CRP were estimated. Results: Serum hs-CRP was significantly associated with measures of obesity such as waist circumference (OR = 13.54, p = 0.0001) and body mass index (OR = 4.71, p = 0.046) in type II DM. Moreover, serum hs-CRP in the upper tertile compared with the lower two tertiles resulted in an odds' ratio of 7.13 for increased BP which was statistically significant, p = 0.0006. In addition, serum hs-CRP was positively correlated with systolic (r = + 0.64) and diastolic (r = + 0.62) blood pressure in type II DM. Conclusion: Obesity and increased BP was well associated and positively correlated with serum hs-CRP in type II DM. Controlling body weight and blood pressure may reduce the chance of an increase in serum hs-CRP and aid these patients experience fewer deaths from CVD and Coronary heart disease. Chatt Maa Shi Hosp Med Coll J; Vol.25 (2); July 2026; Page 16-20
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Hossain et al. (2026) conducted an observational in Type II Diabetes Mellitus (n=126). Upper tertile of serum hs-CRP (>= 9.70 mg/L) vs. Lower two tertiles of serum hs-CRP (< 9.70 mg/L) was evaluated on Central obesity (waist circumference >= 90 cm in men, >= 80 cm in women) (OR 13.54, p=0.0001). Elevated serum hs-CRP in type II diabetes is strongly associated with central obesity (OR 13.54, p=0.0001), high BMI (OR 4.71, p=0.046), and increased blood pressure (OR 7.13, p=0.0006).
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