Key result
Dyslipidemia and hypertension are strongly linked to obstructive CAD in young women.
Why the study?
CAD in young women is increasingly identified with atypical presentations and nonobstructive disease, prompting evaluation of the clinical profile, angiographic characteristics, and factors associated with obstructive CAD and multivessel disease.
Are cardiovascular risk factors such as dyslipidemia, hypertension, and diabetes associated with obstructive coronary artery disease and multivessel disease in young Indian women undergoing coronary angiography?
Observational (n=82)
No
Are cardiovascular risk factors such as dyslipidemia, hypertension, and diabetes associated with obstructive coronary artery disease and multivessel disease in young Indian women undergoing coronary angiography?
In young Indian women undergoing angiography, half had obstructive CAD linked to hypertension and dyslipidemia, while half had nonobstructive or normal coronaries, highlighting both modifiable risk factors and MINOCA/ANOCA mechanisms.
Answers are grounded in this paper and cite their sources.
May inform risk stratification before angiography in young women; leaves open prospective validation of these associations.
Background: Coronary artery disease (CAD) in young women is being increasingly identified, often with atypical presentations and a higher prevalence of nonobstructive disease. This study aimed to evaluate the clinical profile, angiographic characteristics, and factors associated with obstructive CAD and multivessel disease. Materials and Methods: A retrospective observational study of 82 young women undergoing coronary angiography. Clinical features, risk factors, left ventricular function, and angiographic findings were analyzed. Results: Most patients were aged 41–45 years (53.7%). Dyslipidemia (52.4%) and hypertension (50%) were the most common risk factors. Chest pain (85.4%) predominated, with over half presenting as acute coronary syndromes (ACSs). Obstructive CAD was present in 50%, most commonly as single-vessel disease (30.5%) with predominant involvement of the left anterior descending. Nonobstructive CAD (26.8%) and normal coronaries (23.2%) were also common. Hypertension ( P = 0.001) and dyslipidemia ( P < 0.0001) were significantly associated with obstructive CAD, while diabetes ( P = 0.002) was significantly associated with multivessel disease. Conclusion: CAD in young women often presents as ACS and is significantly associated with dyslipidemia and hypertension, while diabetes is significantly associated with multivessel disease, reflecting greater disease severity. A substantial proportion had nonobstructive disease suggestive of the myocardial infarction with nonobstructive coronary arteries/angina with nonobstructive coronary arteries spectrum, emphasizing the role of microvascular mechanisms and the need for early diagnosis and risk factor control.
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Sridevi et al. (2026) conducted an observational in Coronary artery disease in young women undergoing coronary angiography (n=82). Cardiovascular risk factors (dyslipidemia, hypertension, diabetes) vs. Absence of respective cardiovascular risk factors was evaluated on Obstructive coronary artery disease on coronary angiography (p=<0.0001). Dyslipidemia (P < 0.0001) and hypertension (P = 0.001) were significantly associated with obstructive CAD (present in 50%) in young women undergoing angiography.
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