Key result
Meta-analysis evaluates Thoraflex Hybrid prosthesis for early mortality and 5-year survival in arch replacement.
Why the study?
What are the early and mid-term outcomes, specifically early mortality, of total aortic arch replacement using the Thoraflex Hybrid frozen elephant trunk prosthesis?
Meta-Analysis
What are the early and mid-term outcomes, specifically early mortality, of total aortic arch replacement using the Thoraflex Hybrid frozen elephant trunk prosthesis?
This systematic review and meta-analysis protocol/registration outlines the evaluation of early mortality and mid-term outcomes for the Thoraflex Hybrid frozen elephant trunk prosthesis in total aortic arch replacement.
Answers are grounded in this paper and cite their sources.
Pooled Thoraflex FET outcomes support selective use; leaves open need for randomized trials on durability and subgroups.
Systematic review and meta-analysis of proportions on outcomes of total aortic arch replacement with the frozen elephant trunk technique using the Thoraflex Hybrid prosthesis (Terumo Aortic). PubMed/MEDLINE (December 2004 to 13 October 2026) and Scopus (2004–2026) were searched, with backward citation tracking, for original cohorts of at least 10 patients reporting Thoraflex-specific outcomes. When centres or registries reported overlapping series, only the largest entered the primary analysis. The primary outcome is early (in-hospital or 30-day) mortality; secondary outcomes are stroke, spinal cord injury, new renal replacement therapy, recurrent laryngeal nerve palsy, re-exploration for bleeding, distal aortic reintervention, distal stent-graft-induced new entry and survival at 1 and 5 years. Proportions are pooled with random-effects generalized linear mixed models, with subgroup analyses by acuity, meta-regression, sensitivity analyses, MINORS risk-of-bias assessment and GRADE certainty ratings. This is a retrospective registration: the PubMed-based analysis was complete when it was registered, and all 584 records from both databases were being screened by two independent reviewers.
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Bakogiannis et al. (2026) conducted a meta-analysis in Aortic arch disease requiring total aortic arch replacement. Total aortic arch replacement with the frozen elephant trunk technique using the Thoraflex Hybrid prosthesis was evaluated on Early (in-hospital or 30-day) mortality. Total aortic arch replacement with the Thoraflex Hybrid prosthesis is being evaluated across 584 screened records for early mortality and 5-year survival.
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