Key result
Plasma homocysteine levels rise with age and peak at ~25 µmol/L in hypertensive patients.
Why the study?
Homocysteine may contribute to vascular injury and cardiovascular disease, prompting description of plasma homocysteine concentrations and cardiovascular risk profiles in adults with cardiovascular or thromboembolic diseases in Morocco.
Observational (n=52)
No
In a small Moroccan cohort of adults with cardiovascular or thromboembolic disease, plasma homocysteine levels varied descriptively by age, sex, and comorbidities such as hypertension, though the lack of a control group and statistical testing precludes causal inference.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for homocysteine monitoring in older hypertensives; leaves open its role in cardiovascular risk prediction.
Homocysteine may contribute to vascular injury and cardiovascular disease. This study described plasma homocysteine concentrations in 52 adults with cardiovascular or thromboembolic diseases at Mohammed VI University Hospital of Oujda, Morocco. Patients underwent homocysteine testing between January 2019 and July 2024. Clinical and laboratory data were analyzed descriptively according to age, sex, cardiovascular risk factors, vitamin status, and diagnosis. Mean age was 51.34 years; 28 patients were men. Mean homocysteine concentrations increased with age, from 5.5 μmol/L in patients younger than 20 years to 20.40 μmol/L in those older than 60 years. Concentrations were higher in women than men (16.87 vs 14.98 μmol/L) and highest in patients with hypertension (24.85 μmol/L). Vitamin B9 and B12 deficiencies were associated with slightly higher concentrations. These findings suggest age- and risk-factor-related variation; however, the descriptive design and lack of a control group preclude causal conclusions.
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Krimi et al. (2026) conducted an observational in Cardiovascular or thromboembolic diseases (myocardial infarction, stroke, deep vein thrombosis, pulmonary embolism) (n=52). Plasma total homocysteine concentration across cardiovascular risk profiles was evaluated on Distribution of plasma total homocysteine (tHcy) concentrations (µmol/L). Mean plasma homocysteine levels increased with age from 12.70 µmol/L (18-39 years) to 20.40 µmol/L (>60 years) and were highest in hypertensive patients (24.85 µmol/L).
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