What question did this study set out to answer?

To quantify vascular disease risk associated with elevated plasma homocysteine and evaluate potential interactions with traditional cardiovascular risk factors.

June 11, 1997

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.

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Authors

IGIan M. GrahamUniversity of Milan

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Implication

Case-control study demonstrates elevated homocysteine doubles vascular disease risk in younger adults, highlighting synergistic effects with smoking and hypertension.

Key Points

To quantify vascular disease risk associated with elevated plasma homocysteine and evaluate potential interactions with traditional cardiovascular risk factors.
Multicenter case-control study conducted across 19 centers in 9 European countries, enrolling 750 cases with cardiac, cerebral, or peripheral atherosclerotic vascular disease and 800 controls younger than 60 years.
Assessed fasting plasma total homocysteine, post-methionine-loading (100 mg/kg) homocysteine levels, plasma cobalamin, pyridoxal 5'-phosphate, red blood cell folate, serum cholesterol, blood pressure, and smoking status.
Fasting total homocysteine in the top fifth versus the bottom four fifths of controls conferred an independent relative risk of 2.2 (95% CI, 1.6–2.9) for vascular disease, with a dose-response gradient.
Standardized methionine-loading identified an additional 27% of vascular disease cases at risk beyond fasting measurements alone.
Elevated fasting homocysteine demonstrated a more than multiplicative risk interaction with smoking and hypertension, while B-vitamin levels (folate, cobalamin, pyridoxal phosphate) correlated inversely with homocysteine.

Cite This Study

Ian M. Graham (1997) studied this question.

synapsesocial.com/papers/6a7d690bc66da78fab8b3682 https://doi.org/10.1001/jama.1997.03540460039030

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Implication

Case-control study demonstrates elevated homocysteine doubles vascular disease risk in younger adults, highlighting synergistic effects with smoking and hypertension.

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.

Discussion

Member takes

Implication

Key Points

Cite This Study

Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.

Discussion

Member takes

Implication

Key Points

Cite This Study

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