Key result
In 3,216 individuals free of cardiovascular disease, increased homocysteine levels were significantly associated with impaired fibrinolytic potential, indicated by elevated PAI-1 and TPA antigen levels.
Why the study?
Are increased homocysteine levels associated with impaired fibrinolytic potential in individuals free of cardiovascular disease?
Observational (n=3,216)
Are increased homocysteine levels associated with impaired fibrinolytic potential in individuals free of cardiovascular disease?
Increasing homocysteine levels are associated with impaired fibrinolytic potential, suggesting a mechanism by which hyperhomocysteinemia increases cardiovascular risk.
Supports hyperhomocysteinemia as a potential thrombotic mechanism; hypothesis-generating and should not yet change practice.
No takes yet. Share an insight, caveat, or question.
D’Agostino et al. (2002) conducted an observational in Free of cardiovascular disease (n=3,216). Increased homocysteine levels was evaluated on Hemostatic risk factors including plasminogen activator inhibitor (PAI-1), tissue plasminogen activator (TPA) antigen, von Willebrand factor, and fibrinogen levels. In 3,216 individuals free of cardiovascular disease, increased homocysteine levels were significantly associated with impaired fibrinolytic potential, indicated by elevated PAI-1 and TPA antigen levels.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: