Key result
Transradial access cuts mortality ~29% vs transfemoral access, with fewer bleeding and vascular complications.
Why the study?
Although transradial access is the preferred approach for percutaneous coronary angiography and intervention, anatomical variation, access site difficulties, and procedural complications can limit success, creating the need for a practical, comprehensive resource.
Does transradial access reduce vascular complications, bleeding, and mortality compared with transfemoral access in patients undergoing coronary angiography and percutaneous coronary intervention?
Does transradial access reduce vascular complications, bleeding, and mortality compared with transfemoral access in patients undergoing coronary angiography and percutaneous coronary intervention?
This comprehensive narrative review synthesizes the anatomic basis, clinical trial evidence, technical strategies, and complication management for transradial coronary angiography and intervention, reinforcing its role as the preferred standard-of-care access route.
Answers are grounded in this paper and cite their sources.
Supports transradial access to lower mortality and complications; leaves open optimal selection and generalizability in contemporary settings.
Transradial access has become the preferred approach for percutaneous coronary angiography and intervention, largely because this technique reduces vascular complications, bleeding, costs, and patient discomfort compared with transfemoral access. However, anatomical variation, access site difficulties, procedural complications, and other factors can limit success. This review provides a comprehensive overview of the anatomic basis of transradial access, including radial artery anatomy, patient and access site selection, procedural considerations, complications, and emerging applications. This review also highlights key clinical trial data supporting the benefits of transradial access and discusses future directions in technique and technology. Our goal is to provide a practical, comprehensive resource for successful use of this approach.
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Diaz et al. (2026) conducted a review in Coronary artery disease undergoing coronary angiography and percutaneous coronary intervention. Transradial access (TRA) vs. Transfemoral access (TFA) was evaluated. Transradial access reduces all-cause mortality (OR 0.71), bleeding (OR 0.53), and vascular complications (OR 0.23) compared with transfemoral access in coronary interventions.
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