Key result
Microstructure-based phase-field modeling accurately reproduces aortic dissection mechanics across multidirectional tissue tests.
This computational modeling study demonstrates that incorporating image-based microstructural heterogeneity into a phase-field model can qualitatively reproduce experimental crack initiation and propagation patterns in the aortic wall, representing an initial step toward estimating aortic dissection risk from intramural structure.
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Supports microstructure-based aortic modeling; leaves open prospective clinical validation before any risk-stratification use.
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Simon et al. (2026) studied Aortic dissection. Microstructure-based phase-field finite element model vs. Experimental porcine and rabbit aortic tissue mechanical testing data was evaluated on Relative error of model calibration against experimental mechanical testing data. Microstructure-based phase-field modeling reproduced aortic crack initiation and propagation with calibration errors of 8%, 13%, 28%, and 33% across uniaxial, biaxial, peeling, and lapping tests.