Key result
Aortic intramural injection induces ~25% wall swelling at low flow and outer-medial delamination at higher rates.
Why the study?
Does varying biaxial wall loading, injection rate, and needle gauge alter the mechanical and microstructural determinants of intramural injection-driven medial delamination in porcine descending thoracic aortas?
Does varying biaxial wall loading, injection rate, and needle gauge alter the mechanical and microstructural determinants of intramural injection-driven medial delamination in porcine descending thoracic aortas?
This ex vivo biomechanical study demonstrates that intramural fluid injection in the aortic media behaves as a hydraulic fracture process in a layered poroelastic tissue, transitioning from interlamellar permeation and wall swelling at low rates to abrupt fracture-like delamination at high hydraulic forcing and axial stretch.
Answers are grounded in this paper and cite their sources.
Should not yet inform clinical practice; leaves open whether intramural fluid dynamics drive human aortic delamination.
No abstract yet. The journal hasn't published one we can show.
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Cavinato et al. (2026) studied Aortic dissection (ex vivo porcine thoracic aorta model). Intramural fluid injection under biaxial extension-distension vs. Varied axial stretch (1.1 vs. 1.3), injection rates (1 vs. 2 vs. 50 mL/min), and needle gauges (25G vs. 30G) was evaluated on Medial lamellar delamination and injection pressure-volume mechanics. Intramural fluid injection in porcine thoracic aortas caused ~25% wall swelling at 2 mL/min and outer-media delamination at 90 kPa peak pressure at 50 mL/min.