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Desmosomal deficiency and selective downregulation of integrin β1D are associated with RyR2-Ser2030 hyper-phosphorylation and calcium-mediated arrhythmogenesis in experimental and human ARVC.
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This editorial highlights evidence of a desmosome-dyad crosstalk involving integrin β1D downregulation and RyR2 hyper-phosphorylation in ARVC, pointing to RyR2 blockers (such as flecainide) as potential targeted antiarrhythmic therapies.
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Delmar et al. (2020) conducted an editorial in Arrhythmogenic right ventricular cardiomyopathy (ARVC). Desmosomal deficiency and selective downregulation of integrin β1D are associated with RyR2-Ser2030 hyper-phosphorylation and calcium-mediated arrhythmogenesis in experimental and human ARVC.
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