Why the study?
What are the long-term outcomes and prognostic factors in ARVD/C patients and their family members?
What are the long-term outcomes and prognostic factors in ARVD/C patients and their family members?
Long-term outcomes in ARVD/C are favorable when diagnosed and treated, with ICDs playing a key role in index patients and genetic/symptom screening important for family members.
Answers are grounded in this paper and cite their sources.
Supports family screening and ICD use in ARVD/C; leaves open prospective validation of risk stratification.
Long-term outcome was favorable in diagnosed and treated ARVD/C index-patients and family members. Outcome in index-patients was modulated by implantable cardioverter-defibrillator implantation, but not by mutation status and familial background of disease. One third of family members developed ARVD/C. Outcome in family members was determined by symptoms at first evaluation and mutations.
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Groeneweg et al. (2015) studied this question.
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