Application of Platelet-rich Plasma Therapy in Assisted Reproductive Technology

Platelet-rich plasma (PRP) has emerged as a promising autologous biological therapy in the field of assisted reproductive technology (ART). Rich in growth factors and bioactive molecules, PRP is believed to enhance endometrial receptivity, promote tissue regeneration, and modulate local immune responses, thereby improving implantation potential. This review aims to summarize current evidence regarding the application of PRP in reproductive medicine, particularly in patients with thin endometrium, recurrent implantation failure, primary ovarian insufficiency, and poor ovarian response. Although several clinical studies have demonstrated promising improvements in endometrial thickness, clinical pregnancy rates, and live birth rates, the overall quality of evidence remains limited and inconsistent. The lack of standardization in PRP preparation and application complicates result comparison, and despite its safety due to its autologous origin, PRP is still considered an experimental adjunct therapy in ART. Well-designed randomized controlled trials are urgently needed to establish standardized PRP protocols and confirm its efficacy in reproductive medicine.