Comparative study of platelet-rich plasma in assisted reproductive technology: Impact on embryo quality and success rates

Objective: This study aimed to evaluate the impact of female-derived platelet-rich plasma (PRP) on embryo quality and success rates in assisted reproductive techniques (ART) through a prospective randomized controlled trial, with all procedures conducted following ethical registration and approval. Methods: We used the PRP in ART procedures with gametes and embryos. We used intracytoplasmic sperm injection (ICSI) to fertilize the eggs. We conducted a RCT comparing a group treated with PRP to a control group from the same patient. This method helped us directly assess the impact of PRP on the quality of gametes and embryos. We performed a statistical analysis using SPSS to compare fertilization rates, blastocyst formation rates, and pregnancy outcomes between the two groups. Results: The findings suggest that PRP treatment enhances embryo quality. The PRP group demonstrated significantly higher average fertilization rates (2.80 vs. 1.93 from 3.27 used in ICSI, p = 0.004) and blastulation rates (1.60 vs. 0.73, p = 0.008), as well as superior pregnancy and implantation rates (53% vs. 27%, p = 0.027; 40% vs. 18%, p = 0.039), indicating the potential effectiveness of PRP in improving outcomes in ART. Conclusion: PRP in ART protocols enhances embryo quality and improves pregnancy outcomes. It offers a promising option for couples undergoing medical assisted procedures