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G protein-coupled receptor 68 (GPR68/OGR1) is a proton-sensing membrane receptor which plays an important role in the processes of inflammation, oncogenesis, and bone homeostasis. In this study, a comprehensive structure-based virtual screening of 19 small molecules which were obtained from the ZINC database, was conducted using the predicted structure of GPR68 based on AlphaFold2 model AF-Q15743-F1-model_v6.pdb.
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Darius Hadaegh (2026) studied this question.
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