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A 68Ga-substituted Keggin polyoxotungstate is synthesized as a fully inorganic PET tracer in which the radiometal is stabilized within the lacunary site of the Keggin framework. The compound achieves greater than 96% radiochemical purity within 60 minutes and shows higher cellular uptake than both 68GaCl3 and 68Ga-oxine in CHO-K1 cells, with progressive intracellular accumulation and low cytotoxicity, establishing polyoxometalates as a new scaffold for inorganic PET cell tracers. More in the Research Article e9529520, Nadiia I. Gumerova, Annette Rompel, and co-workers.
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Duvanova et al. (2026) studied this question.
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