Key result
Strontium ranelate improves central hemodynamics, cardiovascular remodeling, and diastolic filling in hypertensive postmenopausal women.
Why the study?
The study aimed to evaluate the effects of the bone metabolism modulator strontium ranelate on parameters of cardiovascular remodeling in women with postmenopausal osteoporosis and arterial hypertension.
Does adding strontium ranelate to antihypertensive therapy and calcium supplementation improve parameters of cardiovascular remodeling in women with postmenopausal osteoporosis and arterial hypertension?
Does adding strontium ranelate to antihypertensive therapy and calcium supplementation improve parameters of cardiovascular remodeling in women with postmenopausal osteoporosis and arterial hypertension?
Adding strontium ranelate to standard antihypertensive and calcium therapy was reported to improve central hemodynamics, cardiovascular remodeling, and diastolic filling in hypertensive women with postmenopausal osteoporosis.
Answers are grounded in this paper and cite their sources.
Strontium ranelate effects on cardiovascular remodeling remain uncertain in this population; hypothesis-generating data require confirmation in randomized trials.
The trial was aimed at studying the effects of the modulator of bone metabolism - strontium ranelate on the parameters of cardiovascular remodeling in women with postmenopausal osteoporosis (OP) and arterial hypertension (AH). This effect includes the results of study of strontium ranelate in 48 women with postmenopausal osteoporosis AH 1-2 degrees and moderate or high cardiovascular risk. During 36 weeks 25 patients, in addition to antihypertensive therapy and calcium supplementation received strontium ranelate (Bivalos) 2 g / day. Bone mineral density (BMD) was evaluated by dual energy X-ray absorptiometry. The effect of strontium ranelate treatment on the thickness of the intima-media of the carotid artery (IMT) by the method of duplex scanning on structural and functional parameters of the heart by echocardiography also evaluated. Adding of strontium ranelate to the antihypertensive treatment and calcium supplementation in women with postmenopausal OP and AH has a positive effect on central hemodynamics, cardiovascular remodeling and diastolic filling.
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Khozyainova et al. (2010) studied Postmenopausal osteoporosis and arterial hypertension (n=48). Strontium ranelate vs. Antihypertensive therapy and calcium supplementation alone was evaluated on Parameters of cardiovascular remodeling, central hemodynamics, and diastolic filling (including carotid intima-media thickness and echocardiographic structural/functional heart parameters). Strontium ranelate 2 g/day for 36 weeks in 25 of 48 hypertensive postmenopausal women positively affected central hemodynamics, cardiovascular remodeling, and diastolic filling.
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