Why the study?
In roughly 90-95% of arterial hypertension cases, no single definitive cause can be identified, prompting this analysis of the underlying genetic, molecular, and physiological mechanisms.
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This review highlights the complex genetic, molecular, and physiological mechanisms underlying essential arterial hypertension, emphasizing its polygenic nature and the need for individualized prevention and treatment strategies.
Ushbu maqolada arterial gipertoniyaning rivojlanishida ishtirok etuvchi genetik, molekulyar va fiziologik mexanizmlar tahlil qilinadi. Jahon sog'liqni saqlash tashkilotining 2023-yilgi hisobotiga ko'ra, dunyoda 30–79 yoshdagi taxminan 1,28 milliard odam gipertoniyadan aziyat chekadi. Ko'pchilik hollarda (taxminan 90–95%) gipertoniyaning aniq bitta sababini topib bo'lmaydi. Bunday shakl essensial (birlamchi) gipertoniya deb ataladi. Zamonaviy fan uni yagona kasallik emas, balki genetik moyillik, atrof-muhit va ko'plab biologik tizimlar o'zaro ta'sirining natijasi sifatida ko'radi. Shuningdek, gipertoniyaning irsiy xususiyatlari, poligenik tabiatga ega ekanligi va genetik omillarning turmush tarzi bilan o'zaro ta'siri ko'rib chiqiladi. Zamonaviy ilmiy adabiyotlar tahlili arterial gipertoniyani ko'p omilli kasallik sifatida tushunish, uning xavfini erta baholash va individual profilaktika hamda davolash yondashuvlarini rivojlantirish muhimligini ko'rsatadi.
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Zilolaxon Isaqova Hayrulla qizi (2026) conducted a review in Arterial hypertension (essential hypertension). Genetic, molecular, and physiological mechanisms was evaluated on Development of essential arterial hypertension.
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