Key result
TG/HDL-C ratio shows modest discriminatory ability for insulin resistance in young adults with ~0.64 AUC.
Why the study?
The TG/HDL-C ratio may help identify metabolic abnormalities, warranting evaluation of its association with insulin resistance, discriminatory performance, and optimal cutoff in young Mexican adults.
Does the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio accurately identify insulin resistance (HOMA-IR >2.5) in young Mexican adults?
Cross-Sectional (n=346)
No
Does the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio accurately identify insulin resistance (HOMA-IR >2.5) in young Mexican adults?
In young Mexican adults, the TG/HDL-C ratio has only a modest association with HOMA-IR and limited sensitivity (37.5% at cutoff 2.558), indicating it should be used as a complementary cardiometabolic marker rather than a standalone screening test for insulin resistance.
Answers are grounded in this paper and cite their sources.
Modest TG/HDL-C performance precludes routine clinical use for insulin resistance screening; leaves open need for prospective validation in ethnic cohorts.
Background and Objective: The Triglyceride-To-High-Density Lipoprotein Cholesterol (TG/HDL-C) ratio may help identify metabolic abnormalities. This study evaluated its association with insulin resistance and its discriminatory performance and optimal cutoff in young Mexican adults. Materials and Methods: This cross-sectional study included 346 university students aged 18–30 years from the University of Guadalajara. Insulin resistance was defined as a homeostatic model assessment of insulin resistance (HOMA-IR) value >2.5. Associations were assessed using correlation and linear regression analyses. Discriminatory performance and the optimal cutoff were evaluated using Receiver Operating Characteristic (ROC) analysis and the Youden index. Results: Participants had a mean age of 20.8 ± 2.0 years, and 73.7% were women. Overall, 23.1% met the criterion for insulin resistance. The TG/HDL-C ratio was higher in participants with insulin resistance than in those without it (2.35 ± 1.61 vs. 1.70 ± 1.00, p < 0.001) and was positively correlated with HOMA-IR (ρ = 0.246, p < 0.001). The area under the ROC curve was 0.635 (95% CI: 0.559–0.705). The optimal cutoff was 2.558, with 37.5% sensitivity and 86.8% specificity. In sex-stratified analyses, the AUC was 0.656 in women and 0.579 in men. Conclusion: The TG/HDL-C ratio showed a modest association with insulin resistance and limited discriminatory ability. The cutoff had low sensitivity despite relatively high specificity; external validation is needed before application in other populations.
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Rosario Lizette Uvalle Navarro (2026) conducted a cross-sectional in Insulin resistance in young adults (n=346). Triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio vs. Participants without insulin resistance (HOMA-IR ≤2.5) was evaluated on Identification of insulin resistance (defined as HOMA-IR >2.5) (AUC 0.635 (Spearman's ρ = 0.246), 95% CI 0.559–0.705, p=<0.001). The TG/HDL-C ratio showed modest discriminatory ability for identifying insulin resistance in young Mexican adults (AUC 0.635, 95% CI 0.559–0.705; optimal cutoff 2.558).
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