Key result
Aerobic exercise-induced SBP reductions link to lower cardiac output only in elevated BP.
Why the study?
Whether postexercise blood pressure reductions are associated with changes in cardiac output and its components, and whether these relationships depend on baseline blood pressure status, was examined.
Does aerobic exercise reduce postexercise blood pressure in association with changes in cardiac output and its components across different baseline blood pressure statuses?
Meta-Analysis (n=1,026)
Does aerobic exercise reduce postexercise blood pressure in association with changes in cardiac output and its components across different baseline blood pressure statuses?
Answers are grounded in this paper and cite their sources.
Postexercise systolic blood pressure reductions are significantly associated with reductions in cardiac output in individuals with elevated resting blood pressure, but not in those with normal blood pressure.
OBJECTIVE: To examine whether postexercise blood pressure (BP) reductions are associated with changes in cardiac output (CO) and its components and whether these relationships depend on baseline BP status. METHODS: This systematic review and meta-analysis (PROSPERO: CRD42021256569) included studies assessing BP and central hemodynamic responses at least 30 min after aerobic exercise. Random- and mixed-effects models and meta-regression examined associations between BP and CO, stroke volume (SV), and heart rate (HR), stratified by baseline BP status. RESULTS: Fifty-six trials were included (101 interventions; 1026 participants, 31.2 ± 5.1 years, 120.4 ± 8.9/72.3 ± 7.6 mmHg). Aerobic exercise reduced systolic, diastolic, and mean arterial pressure. Meta-regression analyses revealed that the association between BP reduction and central hemodynamic responses differed according to baseline BP. In individuals with normal BP, no associations between BP and CO, SV, or HR remained significant after correction for multiple testing. In contrast, in individuals with elevated BP, greater reductions in SBP were associated with greater reductions in CO [slope = 0.659; 95% confidence interval (95% CI), 0.268-1.051; P < 0.001], and this association remained significant after false discovery rate and Bonferroni corrections. No other associations between BP and CO, SV, or HR remained significant. CONCLUSION: Greater postexercise reductions in SBP were associated with reductions in CO in individuals with elevated BP, whereas no consistent association was observed in individuals with normal BP. These findings indicate that the relationship between postexercise BP and hemodynamic responses differs according to baseline BP status, with a stronger association between SBP and CO responses in individuals with elevated BP, without establishing a causal relationship.
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Silva et al. (2026) conducted a meta-analysis in Postexercise hypotension across resting blood pressure status (normal vs. elevated BP) (n=1,026). Aerobic exercise was evaluated on Association between postexercise systolic blood pressure (SBP) reduction and cardiac output (CO) reduction in individuals with elevated BP (slope 0.659, 95% CI 0.268-1.051, p=<0.001). Aerobic exercise-induced SBP reductions were associated with cardiac output reductions in individuals with elevated BP (slope 0.659; 95% CI 0.268-1.051; P<0.001), but not in those with normal BP.
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