Key result
Adding L-arginine and dihydroquercetin reduces 12-week office systolic BP by ~10 mmHg vs standard therapy.
Why the study?
The study aimed to improve the effectiveness of treatment in stage II arterial hypertension patients who have had COVID-19 by providing pharmacoepidemiologic and clinical substantiation for including an L-arginine and dihydroquercetin complex in combined antihypertensive pharmacotherapy.
Does the addition of L-arginine and dihydroquercetin to combined antihypertensive pharmacotherapy and statins improve blood pressure control, endothelial function, and lipid profiles in patients with stage II arterial hypertension who have had COVID-19?
RCT (n=109)
Randomly distributed into 2 groups
Does the addition of L-arginine and dihydroquercetin to combined antihypertensive pharmacotherapy and statins improve blood pressure control, endothelial function, and lipid profiles in patients with stage II arterial hypertension who have had COVID-19?
Adding L-arginine and dihydroquercetin to combined antihypertensive therapy and statins accelerated and enhanced blood pressure reduction, restored endothelial function, and improved lipid profiles over 12 weeks in stage II hypertensive patients with recent COVID-19.
Answers are grounded in this paper and cite their sources.
May support adjunctive L-arginine plus dihydroquercetin for post-COVID hypertension; hypothesis-generating and requires randomized confirmation before practice change.
Introduction: The article presents information on the dynamics of office blood pressure in patients with arterial hypertension stage II who have had COVID-19 during antihypertensive pharmacotherapy (AHPT), including the L-arginine complex (500 mg tablets once a day) + dihydroquercetin (25 mg tablets twice a day). The aim was to improve the effectiveness of treatment of COVID-19-treated HD patients by pharmacoepidemiologic and clinical substantiation of inclusion of L-arginine + dihydroquercetin complex in the composition of combined AHPT. Materials and Methods: In order to achieve the goal, we developed a research design, which involved two stages. During the 1st stage, we designed a questionnaire for pharmacy visitors, which in agreement with the management of pharmacies, pharmacists offered visitors to fill out when the latter buy antihypertensive officinal drugs (AHOD). The questionnaire survey of pharmacy visitors in Donetsk was conducted from December 2021 till February 2023. A total of 1118 pharmacy visitors with HD participated in the questionnaire survey. The 2nd stage of the study included HD patients who had undergone COVID-19. Patients who met the inclusion criteria and had no exclusion criteria were included in the study. Results and Discussion. The proposed treatment has been shown to be more effective than standard antihypertensive pharmacotherapy. This is manifested by the achievement of normotonic values of office systolic and diastolic blood pressure by the end of the 2nd week of treatment (<140/90 mmHg) compared to standard antihypertensive pharmacotherapy, in which this result was achieved only by the end of the 4th week of treatment. A decrease in systolic blood pressure levels to <130 mm Hg and diastolic blood pressure to <80 mm Hg was achieved starting from the 4th week of treatment only when the L-arginine + dihydroquercetin complex was included in the combined antihypertensive pharmacotherapy. Conclusion: Inclusion of L-arginine complex (500 mg tablets once a day, for 12 weeks according to the 2 weeks-on/1 week-off regimen) + dihydroquercetin (25 mg tablets twice a day, for 12 weeks according to the 4 weeks-on/1 week-off regimen) as a part of combined AHPT (including statins) in patients with stage II HD, who underwent COVID-19, increased its efficacy, which was manifested by achievement of normotonic values of office SAP and DAP (<140/90 mm Hg) by the end of the 2nd week of treatment compared to combined AHPT (including statins) in comparison with combined AHPT (by the end of the 4th week of treatment).
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Naletova et al. (2025) conducted an RCT in Stage II arterial hypertension (hypertensive disease) after COVID-19 (n=109). L-arginine + dihydroquercetin complex added to combined antihypertensive pharmacotherapy (including statins) vs. Combined antihypertensive pharmacotherapy (including statins) alone was evaluated on Mean office systolic blood pressure (SAP, mm Hg) at 12 weeks (p=<0.05). Adding L-arginine and dihydroquercetin to combined antihypertensive therapy significantly reduced 12-week office systolic BP to 125.7 mm Hg vs 135.5 mm Hg with standard therapy alone (p<0.05).
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