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Fournier’s gangrene (FG) is a rare, rapidly progressive necrotizing soft-tissue infection involving the perineal, genital, and perianal regions. Early diagnosis, broad-spectrum antibiotics, and urgent surgical debridement are essential to reduce morbidity and mortality. We report three male patients aged 50, 65, and 59 years, respectively, all with diabetes mellitus, who presented with FG involving varying anatomical regions. The first patient underwent surgical debridement followed by split-thickness skin grafting. The second, who had extensive perineal and perianal tissue destruction, required debridement, diverting colostomy, vacuum-assisted closure therapy, and reconstructive surgery, followed by colostomy reversal after six weeks. The third patient, with involvement of the external genitalia and right upper inner thigh, underwent debridement and meshed split-thickness skin grafting. All three patients achieved clinical recovery and were discharged. This case series highlights the importance of early recognition, prompt surgical debridement, appropriate antimicrobial therapy, and individualized reconstructive strategies in the successful management of FG.
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Sheikh et al. (2026) studied this question.
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