Diffuse Cutaneous Metastases From Endocervical Adenocarcinoma: A Rare Pattern of Recurrence

Cutaneous metastases from cervical cancer are uncommon and can resemble benign inflammatory or treatment-related dermatoses.We report a 54-year-old woman with International Federation of Gynecology and Obstetrics (FIGO) stage IIIC2 endocervical adenocarcinoma who received carboplatin-paclitaxel chemotherapy followed by cisplatin-based chemoradiotherapy and uterovaginal brachytherapy.Six months after completing locoregional treatment, she developed rapidly progressive erythematous-violaceous plaques and micropapules that began in the inguinal regions and proximal thighs, extended to the abdomen and breasts, and were accompanied by marked vulvar swelling.A skin biopsy showed dermal involvement by a poorly differentiated carcinoma.The tumor was positive for CK7 and p16, showed weak, heterogeneous estrogen receptor (ER) expression, and was negative for CK20 and vimentin.Comparison with the primary cervical tumor supported cutaneous metastasis from the known endocervical adenocarcinoma.Thoracoabdominopelvic computed tomography showed no distant metastatic lesions.This case emphasizes that persistent, progressive, or atypical skin lesions after treatment for cervical cancer require early biopsy.Extensive cutaneous dissemination may occur even in the absence of radiologically detectable distant extracutaneous metastases.