What question did this study set out to answer?

To describe the rare clinical presentation and immunohistochemical evaluation of metastatic breast cancer involving the cervix and endometrium.

August 14, 2026The Permanente JournalOpen Access

Metastatic Breast Cancer to the Cervix and Endometrium Mimicking a Primary Gynecologic Malignancy

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Authors

KBKarina BasmajianArrowhead Regional Medical Center DTDanny ThaiUniversity of Waterloo HGHansi GajanayakeEisenhower Medical Center

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Implication

Case report demonstrates metastatic breast cancer spreading to the cervix and endometrium, highlighting the need to distinguish breast metastases from primary gynecologic malignancies.

Key Points

To describe the rare clinical presentation and immunohistochemical evaluation of metastatic breast cancer involving the cervix and endometrium.
Evaluated a 56-year-old postmenopausal female with known metastatic invasive mammary carcinoma presenting with syncope and heavy vaginal bleeding.
Performed cervical and endometrial biopsies characterized by immunohistochemical staining (GATA3, mammoglobin, TRPS1, p16, p63, CK5/6, and PAX8) and multidisciplinary review.
Cervical biopsy revealed tumor cells positive for GATA3, mammoglobin, TRPS1, AE1/3, and CAM5.2, and negative for PAX8, confirming metastatic breast carcinoma.
Endometrial biopsy showed atypical carcinoma cells positive for p16, p63, and CK5/6, which multidisciplinary evaluation confirmed as metastatic breast disease rather than a primary HPV-associated gynecologic cancer.

Cite This Study

Basmajian et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec71db70b84ec8b9133c1 https://doi.org/10.7812/tpp/26.030

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Implication

Case report demonstrates metastatic breast cancer spreading to the cervix and endometrium, highlighting the need to distinguish breast metastases from primary gynecologic malignancies.

Metastatic Breast Cancer to the Cervix and Endometrium Mimicking a Primary Gynecologic Malignancy

Discussion

Member takes

Implication

Key Points

Cite This Study

Metastatic Breast Cancer to the Cervix and Endometrium Mimicking a Primary Gynecologic Malignancy

Discussion

Member takes

Implication

Key Points

Cite This Study

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