What question did this study set out to answer?

To describe the diagnostic identification, immunohistochemical differentiation, and neoadjuvant management of synchronous primary endometrial and occult breast carcinomas.

August 15, 2026Ochsner JournalOpen Access

Endometrial Carcinoma Unveiling Breast Carcinoma in a Postmenopausal Female: A Case of Synchronous Malignancy

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To describe the diagnostic identification, immunohistochemical differentiation, and neoadjuvant management of synchronous primary endometrial and occult breast carcinomas.
Evaluated a 61-year-old postmenopausal female presenting with abdominal pain and abnormal bleeding using PET/CT, mammography, and clinical breast examinations.
Performed immunohistochemical staining (GATA3, HER2, PAX8, ER, PR) on axillary lymph node and endometrial biopsies alongside germline genetic panel testing.
Administered a regimen of neoadjuvant chemotherapy targeting both distinct primary malignancies.
PET/CT detected occult fluorodeoxyglucose-avid left breast and axillary lesions despite an unremarkable physical examination and normal mammography (BI-RADS 1).
Immunohistochemistry differentiated dual primary tumors, showing GATA3 and HER2 positivity in axillary nodes and PAX8, ER, and PR positivity in endometrial tissue.
Neoadjuvant chemotherapy achieved a pathologic complete response in the breast lesion and marked regression of the endometrial carcinoma.

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Implication

Case report reveals synchronous occult breast and endometrial cancers in a postmenopausal woman, highlighting the value of molecular profiling and advanced imaging.

Cite This Study

Polavarapu et al. (2026) studied this question.

synapsesocial.com/papers/6a80197375c2e31742c8584e https://doi.org/10.31486/toj.25.0116

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Implication

Case report reveals synchronous occult breast and endometrial cancers in a postmenopausal woman, highlighting the value of molecular profiling and advanced imaging.

Endometrial Carcinoma Unveiling Breast Carcinoma in a Postmenopausal Female: A Case of Synchronous Malignancy

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Discussion

Implication

Cite This Study

Endometrial Carcinoma Unveiling Breast Carcinoma in a Postmenopausal Female: A Case of Synchronous Malignancy

Key Points

Discussion

Implication

Cite This Study

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