What question did this study set out to answer?

To explore the rarity of synchronous primary malignancies of the female genital tract and the role of p16 positivity in diagnosis.

The Deceptive Signal: p16 Positivity Suggestive of Human Papilloma Virus Infection Masking a Second Primary Malignancy – A Case Report and Review on Literature

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Case report demonstrates co-occurrence of endometrioid adenocarcinoma and cervical SCC, highlighting diagnosis complexities.

To explore the rarity of synchronous primary malignancies of the female genital tract and the role of p16 positivity in diagnosis.
Presenting case of a 75-year-old woman with vaginal bleeding.
Imaging and histopathological evaluations were conducted.
Laparotomy and radical hysterectomy performed for staging.
Adjuvant radiotherapy administered postoperatively.
Two distinct malignancies identified: endometrioid adenocarcinoma and cervical squamous cell carcinoma.
No metastases detected in nodes or peritoneal regions.
Emphasized the need for careful interpretation of p16 positivity.

Kumar et al. (2026) studied this question.

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