Association of the TyHGB index with hyperuricemia in adults aged 65 years and older

The triglyceride high-density lipoprotein cholesterol-glucose body index (TyHGB) is a newly proposed metabolic marker. Our objective is to investigate the association between TyHGB and hyperuricemia prevalence in the elderly population. Data were analysed from 5730 adults aged 65 years or older in the National Health and Nutrition Examination Survey (NHANES), with an external validation sample from Kunshan Jinxi People’s Hospital, China. Logistic and linear regression, restricted cubic spline (RCS) modeling, and receiver operating characteristic (ROC) analyses were employed to evaluate the associations between TyHGB and hyperuricemia. TyHGB levels were significantly higher in participants with hyperuricemia ( P < 0.001). After adjusting for covariates, TyHGB remained significantly associated with hyperuricemia (OR: 1.141, 95% CI: 1.105–1.178, P < 0.001) and with increased serum uric acid (SUA) levels (β: 4.798, 95% CI: 3.759–5.836, P < 0.001). RCS analysis revealed a nonlinear relationship. ROC analysis further demonstrated that TyHGB had better discriminatory ability compared to other metabolic measures. These associations were also confirmed in the external Kunshan Chinese elderly sample. TyHGB is significantly associated with hyperuricemia, suggesting its potential utility in evaluating the role of metabolic disorders in hyperuricemia.