Application of platelet-rich fibrin (PRF) to improve tissue regeneration in maxillofacial injuries, including trauma and surgically induced tissue damage. (A systematic review)

Objective. To evaluate the effectiveness of platelet-rich fibrin (PRF) for regeneration of bone, soft tissues, neural structures, and dental tissues in traumatic and surgically induced maxillofacial injuries. Materials and methods. A PRISMA 2020 systematic review was conducted using PubMed, eLIBRARY, Google Scholar, Cochrane Library, and reference lists (2010—2025). Of 377 identified records, 38 underwent full-text assessment and 22 were included in the qualitative synthesis. Results. PRF was associated with improved bone regeneration after mandibular fractures, healing after tooth extraction, peripheral nerve recovery, reduced pain and swelling, and enhanced soft-tissue healing. Case reports also suggest potential benefits in avulsed tooth replantation and regenerative endodontics. Considerable heterogeneity in study design and PRF protocols was noted. Conclusion. PRF is a promising autologous adjunct for maxillofacial tissue injuries, but larger standardized randomized trials are needed.