Strategies for the prevention and treatment of hypertension and recent advances

Q: What is the clinical evidence from this study?

Study design: Review. Population: Hypertension. Intervention: Hypertension prevention and treatment strategies (novel drugs, non-pharmacological interventions, interventional devices, precision medicine).

Q: What does this research mean for the field?

Effective management of hypertension requires integrating traditional prevention strategies with cutting-edge advances in novel pharmacotherapies, interventional devices, and AI- and multi-omics-driven precision approaches while addressing critical translation and accessibility barriers. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

陳佳慧; Jinchi Jiang; Xu Rui

doi:10.1016/j.lddd.2026.100650

October 1, 2026Letters in Drug Design & DiscoveryOpen Access

Strategies for the prevention and treatment of hypertension and recent advances

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Key result

Novel drugs, interventional devices, and AI advance hypertension prevention and precision management.

Graphical abstract published by Letters in Drug Design & Discovery — Graphical abstract · Published by Letters in Drug Design & Discovery · CC BY-NC-ND 4.0

Key Points

To review conventional and cutting-edge prevention and treatment strategies for hypertension while identifying key challenges facing clinical practice and public health.
Systematic review synthesizing recent advances in pharmacological, non-pharmacological, interventional, and precision medicine approaches for hypertension management.
Evaluation of core implementation challenges, including clinical translation, therapeutic accessibility, and special-population management controversies.
Highlights novel antihypertensive therapeutics, non-pharmacological modalities, and procedural device-based optimizations alongside multi-omics and artificial intelligence applications for precision intervention.
Identifies substantial barriers impeding hypertension control, including limited clinical translation of precision strategies, restricted access to emerging drugs and technologies, and unresolved management protocols in special populations.

Structured PICO

P

Population

Patients with hypertension

I

Intervention

Novel antihypertensive drugs, non-pharmacological interventions, interventional device-based therapies, and precision prevention and treatment supported by multi-omics and artificial intelligence

Limitations

Insufficient clinical translation of precision prevention strategies
Limited accessibility of new drugs and technologies
Controversies surrounding the management of special populations

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Implication

This review integrates traditional management frameworks with recent advances in pharmacotherapy, device-based interventions, non-pharmacological strategies, and multi-omics/AI-driven precision medicine for hypertension.

Abstract

Hypertension is one of the most prevalent chronic non-communicable diseases globally and the primary risk factor for cardiovascular and cerebrovascular diseases, imposing a substantial burden on both individual health and public health systems. This article systematically reviews prevention and treatment strategies for hypertension, along with recent research advances, and briefly outlines the traditional prevention and treatment framework. This review focuses on elucidating key recent advances in hypertension prevention and treatment. It encompasses the development and application of novel antihypertensive drugs, new strategies in non-pharmacological interventions, technological optimizations in interventional device-based therapies, and progress in precision prevention and treatment supported by multi-omics and artificial intelligence. Concurrently, it analyzes the core challenges currently facing hypertension prevention and treatment. These include the insufficient clinical translation of precision prevention strategies, the limited accessibility of new drugs and technologies, and controversies surrounding the management of special populations. This review aims to integrate traditional experience with cutting-edge advances in hypertension management, providing a reference for clinical practice, public health interventions, and future research.

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Cite This Study

陳佳慧 et al. (2026) conducted a review in Hypertension. Hypertension prevention and treatment strategies (novel drugs, non-pharmacological interventions, interventional devices, precision medicine) was evaluated. Recent advances in hypertension prevention and treatment span novel drugs, interventional devices, and AI-supported precision medicine, though no quantitative results are reported.

synapsesocial.com/papers/6af0db863c845ca7837ced6e https://doi.org/10.1016/j.lddd.2026.100650

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Strategies for the prevention and treatment of hypertension and recent advances

Key Points

Structured PICO

Limitations

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Implication

Abstract

Discussion

Cite This Study

Strategies for the prevention and treatment of hypertension and recent advances

Key Points

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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