Key result
HBV infection is linked to ~45-mg/dL lower total cholesterol compared with healthy controls.
Why the study?
Beyond hepatic injury, hepatitis B virus infection may impair the liver's metabolic functions, including lipid synthesis, transport, and regulation, thereby resulting in alterations in serum lipid profile.
Does Hepatitis B virus infection alter serum lipid profile concentrations compared to healthy controls in adult Nigerian men?
Cross-Sectional (n=60)
No
Does Hepatitis B virus infection alter serum lipid profile concentrations compared to healthy controls in adult Nigerian men?
HBV infection in Nigerian men is associated with significant reductions in serum total cholesterol and HDL-C, indicating hepatic lipid metabolic disruption that may warrant routine lipid monitoring.
Answers are grounded in this paper and cite their sources.
Clinicians should not alter lipid management for HBV; leaves open prognostic implications for future longitudinal studies.
Background: Hepatitis B virus (HBV) infection remains a significant global public health challenge, particularly in sub-Saharan Africa, where persistent infection contributes substantially to liver-related morbidity and mortality. Beyond hepatic injury, HBV infection may impair the liver’s metabolic functions, including lipid synthesis, transport, and regulation, thereby resulting in alterations in serum lipid profile. Objective: This study evaluated serum lipid profile alterations among male patients with HBV infection attending Bowen University Teaching Hospital, Ogbomoso, Nigeria. Methods: A hospital-based, comparative, analytical cross- sectional study was conducted among 60 adult males comprising 30 confirmed HBV-infected patients and 30 HBV-negative apparently healthy controls. HBV infection was confirmed by serological detection of Hepatitis B surface antigen (HBsAg). Socio-demographic and clinical information was obtained using structured interviewer-administered questionnaires. Following an overnight fast, venous blood samples were collected, and serum concentrations of total cholesterol (TC), triglycerides (TG), and high density lipoprotein cholesterol (HDL-C), were determined using standard enzymatic spectrophotometric methods, and low-density lipoprotein cholesterol (LDL-C) were estimated using the Friedewald formula. Data were analyzed using the Statistical Package for Social Sciences (SPSS), and group comparisons were performed using the independent Student’s t-test at a significance level of p < 0.05. Results: HBV-infected participants exhibited significantly lower serum total cholesterol (98.00 ± 10.08 mg/dL vs. 142.83 ± 22.26 mg/dL; p < 0.001) and HDL-C levels (52.00 ± 9.24 mg/dL vs. 93.23 ± 17.73 mg/dL; p < 0.001) compared with controls. However, no significant differences were observed in triglyceride (p = 0.754) and LDL-C concentrations (p = 0.485). Conclusion: HBV infection is associated with significant reductions in serum total cholesterol and HDL-C, suggesting disruption of hepatic lipid metabolic pathways. Routine lipid profile assessment may provide additional clinical insight into metabolic alterations associated with HBV infection and support comprehensive patient management.
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OLANIYAN et al. (2026) conducted a cross-sectional in Hepatitis B virus (HBV) infection (n=60). Hepatitis B virus (HBV) infection vs. HBV-negative apparently healthy controls was evaluated on Serum total cholesterol (TC) concentration (p=< 0.001). HBV infection was associated with lower serum total cholesterol and HDL-C vs controls.
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