Professor Zhang Peiqing’s Stage Treatment and Clinical Experience in Treating Cardiorenal Syndrome Based on the Theory of “Yang Transforming Qi, Yin Forming Form”

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Cardiorenal syndrome (Type 4) with stage 5 chronic kidney disease and congestive heart failure (n=1). Intervention: Modified Shenqi Dihuang Decoction combined with Zhenwu Decoction. Primary outcome: Serum creatinine and clinical symptoms of heart failure.

妞妞 刘

doi:10.12677/acm.2026.16113642

January 1, 2026Advances in Clinical MedicineOpen Access

Professor Zhang Peiqing’s Stage Treatment and Clinical Experience in Treating Cardiorenal Syndrome Based on the Theory of “Yang Transforming Qi, Yin Forming Form”

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Key result

Modified Shenqi Dihuang and Zhenwu Decoction reduced serum creatinine from 520 to 471 μmol/L and relieved orthopnea and edema in a patient with Type 4 cardiorenal syndrome.

Why the study?

This study explores the correlation between the Huangdi Neijing theory that Yang governs qi transformation while Yin constitutes tangible structures and the onset and development of cardiorenal syndrome.

Key Points

To delineate Professor Zhang Peiqing's clinical experience applying the Huangdi Neijing theory of 'Yang transforming Qi, Yin forming Form' to the staged diagnosis and treatment of cardiorenal syndrome.
Characterized the pathogenesis of cardiorenal syndrome as heart and kidney Yang qi deficiency with concurrent stagnation of Yin pathogens, categorized as an underlying deficiency with superficial excess.
Formulated a stage-based herbal therapeutic strategy using formulas such as Shenqi Dihuang decoction, Zhenwu decoction, and Jisheng Shenqi pills to warm Yang, promote qi transformation, and expel dampness and blood stasis.
Evaluated the clinical approach via a detailed case report of a female patient with type 4 cardiorenal syndrome receiving sequential formula adjustments.
Staged differentiation managed early-stage qi and yin deficiency, mid-stage Yang deficiency with fluid retention, and late-stage multi-pathogen stasis through tailored herbal combinations.
In the representative clinical case, staged treatment progressively lowered serum creatinine from 520 umol/L to 498 umol/L and 471 umol/L, while resolving nocturnal orthopnea and alleviating lower extremity edema.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P

Population

1 female patient with Type 4 cardiorenal syndrome, stage 5 diabetic nephropathy, and congestive heart failure treated over approximately 3 months.

I

Intervention

Stage-specific Traditional Chinese Medicine (TCM) therapy based on the theory of 'Yang Transforming Qi, Yin Forming Form': early stage treated with modified Shenqi Dihuang Decoction combined with Jiaotai Pill; middle stage treated with modified Zhenwu Decoction combined with Linggui Zhugan Decoction; late stage treated with modified Jisheng Shenqi Pill combined with Danggui Shaoyao Powder. In the illustrative case, modified Shenqi Dihuang Decoction combined with Zhenwu Decoction was administered orally once daily in two warm doses.

This paper outlines Professor Zhang Peiqing's Traditional Chinese Medicine clinical experience and stage-specific treatment framework for cardiorenal syndrome based on the 'Yang Transforming Qi, Yin Forming Form' theory, illustrated by a clinical case showing improved symptoms and reduced serum creatinine.

Limitations

Requires flexible modification for patients with prominent yin deficiency with effulgent fire or exuberant damp-heat rather than uniform yang-warming.
Acute and critical cases still require comprehensive treatment combined with modern medical interventions.
The theoretical framework requires further validation through larger-sample clinical studies and basic experimental research.
For patients with obvious hyperactivity of fire due to Yin deficiency or exuberant warm-heat, flexible modifications are required rather than blindly warming Yang.
For acute and critical conditions, comprehensive treatment combining modern medical methods is still necessary.
The theoretical framework requires further validation through larger-sample clinical studies and basic experiments.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Should not change cardiorenal syndrome practice; hypothesis-generating for TCM strategies pending controlled trials.

Abstract

Drawing on the Huangdi Neijing's theory that Yang governs qi transformation while Yin constitutes tangible structures, this study explores its correlation with the onset and development of cardiorenal syndrome (CRS).Professor Zhang Peiqing believes that the core pathogenesis of CRS is the deficiency of Yang qi in the heart and kidney, impaired transformation functions, and stagnation of Yin pathogens such as phlegm, blood stasis, dampness, and toxins-characterizing a condition of underlying deficiency with superficial excess.Treatment should be stage-specific, addressing both temporary and permanent solutions: warming Yang qi and transforming the qi to consolidate the foundation, while promoting blood circulation and eliminating dampness to expel Yin pathogens.Attention must also be paid to seeking Yang within Yin and Yin within Yang.This approach often yields favorable clinical outcomes.

Discussion

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Cite This Study

妞妞刘 (2026) conducted a case report in Cardiorenal syndrome (Type 4) with stage 5 chronic kidney disease and congestive heart failure (n=1). Modified Shenqi Dihuang Decoction combined with Zhenwu Decoction was evaluated on Serum creatinine and clinical symptoms of heart failure. Modified Shenqi Dihuang and Zhenwu Decoction reduced serum creatinine from 520 to 471 μmol/L and relieved orthopnea and edema in a patient with Type 4 cardiorenal syndrome.

synapsesocial.com/papers/6af0e999de503f3774140a27 https://doi.org/10.12677/acm.2026.16113642

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Professor Zhang Peiqing’s Stage Treatment and Clinical Experience in Treating Cardiorenal Syndrome Based on the Theory of “Yang Transforming Qi, Yin Forming Form”

Key Points

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Professor Zhang Peiqing’s Stage Treatment and Clinical Experience in Treating Cardiorenal Syndrome Based on the Theory of “Yang Transforming Qi, Yin Forming Form”

Key Points

Study Design

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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