Key result
Better cognitive function is linked to greater 6MWT distance in heart failure patients.
Why the study?
Heart failure is a prevalent condition that is a leading cause of hospitalization and mortality, prompting an investigation into the clinical, socioeconomic, behavioral, and cognitive factors associated with functional capacity.
Are cognitive performance and clinical, socioeconomic, and behavioral factors associated with functional capacity in outpatients with heart failure?
Cross-Sectional (n=82)
Yes
Are cognitive performance and clinical, socioeconomic, and behavioral factors associated with functional capacity in outpatients with heart failure?
Outpatients with heart failure exhibit markedly reduced functional capacity (walking less than half their predicted 6MWT distance), which is significantly associated with cognitive performance, age, sex, clinical follow-up duration, and quality of life.
Answers are grounded in this paper and cite their sources.
Cognitive scores correlated with 6MWT distance in heart failure; hypothesis-generating and should not yet change practice.
Background: Heart failure (HF) is a prevalent clinical condition that significantly impacts patient survival and represents one of the leading causes of hospitalization and mortality.Objective: To analyze the association between functional capacity and clinical, socioeconomic, behavioral, and cognitive factors in individuals with HF.Methods: A cross-sectional study was conducted with 82 patients with HF undergoing outpatient follow-up.Functional capacity was assessed using the six-minute walk test (6MWT) and the sit-to-stand test (STS).Cognitive performance was measured using the mini-mental state examination (MMSE).Sociodemographic and clinical data were obtained from medical records and structured interviews.Results: The sample consisted of 82 patients (63.4% male), with a mean age of 59.4 ± 12.9 years.In the 6MWT, the mean distance walked was significantly lower than the predicted distance (246.8 ± 86.5 m vs. 557.3± 47.5 m; p < 0.001).In the STS, participants performed an average of 15.6 ± 4.8 repetitions (p < 0.001).A positive and statistically significant correlation was observed between MMSE scores and functional capacity assessed by the 6MWT (ρ = 0.290; p = 0.020).Lower functional performance was also associated with older age, male sex, and poorer self-rated quality of life (p < 0.05).Conclusion: In the sample studied, cognitive performance and clinical and sociodemographic factors were associated with functional capacity in individuals with HF.
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Silva et al. (2026) conducted a cross-sectional in Heart failure (n=82). Cognitive performance (Mini-Mental State Examination) and clinical/sociodemographic factors vs. Predicted six-minute walk test distance and subgroup comparisons (<300 m vs ≥300 m in 6MWT; <15 vs ≥15 repetitions in 1-min STS) was evaluated on Functional capacity assessed by the six-minute walk test (6MWT) distance and correlation with cognitive performance (MMSE) (Spearman ρ = 0.290 (MMSE vs 6MWT), p=<0.001 (walked vs predicted 6MWT); 0.020 (MMSE correlation)). Cognitive performance measured by MMSE positively correlated with 6MWT distance (ρ = 0.290; p = 0.020) in heart failure patients whose walked distance was lower than predicted (246.8 vs 557.3 m; p < 0.001).
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