Key result
Asynchronous spot-specific classifiers improve murmur characterization sensitivity by up to ~16 points over multi-input CNNs.
Why the study?
Clinicians characterize heart murmurs by timing, shape, pitch, quality, and grade, whereas most automatic phonocardiogram analysis systems stop at binary detection and do not estimate this richer description.
Can multi-spot phonocardiogram machine learning and deep learning architectures accurately characterize heart murmurs across timing, shape, pitch, grading, and quality in patients with complete four-spot auscultation recordings?
Observational (n=735)
Can multi-spot phonocardiogram machine learning and deep learning architectures accurately characterize heart murmurs across timing, shape, pitch, grading, and quality in patients with complete four-spot auscultation recordings?
Answers are grounded in this paper and cite their sources.
Multi-spot phonocardiogram analysis using late-fusion machine learning and multi-task deep learning can reliably estimate murmur timing, shape, pitch, grade, and quality, enabling automated structured auscultation reports beyond simple binary murmur detection.
Cardiac auscultation traditionally detects the presence of a heart murmur, but clinicians further characterize it by timing, shape, pitch, quality, and grade. Most automatic phonocardiogram analysis systems stop at binary detection and do not estimate this richer description. In this work, we formulate automatic murmur characterization as five patient-level classification tasks and compare three multi-spot strategies on recordings from the aortic, pulmonary, mitral, and tricuspid auscultation locations. First, classical and deep-learning classifiers are trained independently at each location, and predictions are combined via a maximum-severity late-fusion rule. Second, a synchronous multi-input CNN jointly processes one representative segment per location for a single task. Third, a unified multi-input, multi-output CNN predicts all five attributes from one shared multi-spot representation. Using 735 patients from the CirCor DigiScope dataset with complete four-spot recordings, the best late-fusion configurations reach an unweighted mean sensitivity between 85.56% and 93.81% across the five tasks, with class-specific recalls between 80.00% and 100.00% for every relevant category. The multi-input CNN trails late fusion by 7-16 points depending on the task, while the multi-output model reaches values between 72.59% and 79.40%, estimating all five attributes from one shared representation. We further show that naively balancing training data by adding all minority-class segments degrades patient-level performance under the maximum-severity rule, since it introduces non-representative, noisy segments not filtered by the clustering-based segment selection used for evaluation. These results indicate multi-spot murmur characterization is feasible with both fusion-based and jointly learned architectures, outlining a path toward automatic, structured murmur reports complementing binary screening.
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Nogueira et al. (2026) conducted an observational in Heart murmur characterization (valvular heart disease screening) (n=735). Multi-spot phonocardiogram machine learning and deep learning models (asynchronous spot-specific classifiers with maximum-severity late fusion, synchronous multi-input CNN, and unified multi-input multi-output CNN) vs. Comparison across the three multi-spot modeling strategies (late fusion vs synchronous multi-input CNN vs unified multi-input multi-output CNN) was evaluated on Unweighted mean sensitivity (UMS) across five patient-level murmur characterization tasks (timing, shape, pitch, grading, and quality). Asynchronous spot-specific classifiers with late fusion achieved an unweighted mean sensitivity of 85.56% to 93.81% across five murmur characterization tasks, outperforming multi-input CNNs by 7-16%.
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