Key result
Higher Naples Prognostic Score is linked to ~2-fold higher odds of coronary artery ectasia.
Why the study?
Systemic inflammation and impaired nutritional status are believed to play a pivotal role in the pathogenesis of coronary artery ectasia (CAE). Although the Naples Prognostic Score (NPS) is associated with adverse cardiovascular outcomes, its relationship with the presence of CAE needed evaluation.
Is a higher Naples Prognostic Score independently associated with the presence of coronary artery ectasia in patients with chronic coronary syndrome undergoing invasive coronary angiography?
Case-Control (n=139)
No
Is a higher Naples Prognostic Score independently associated with the presence of coronary artery ectasia in patients with chronic coronary syndrome undergoing invasive coronary angiography?
Answers are grounded in this paper and cite their sources.
A higher Naples Prognostic Score, integrating systemic inflammation and nutritional status, is independently associated with the presence of coronary artery ectasia in patients undergoing invasive coronary angiography.
Coronary artery ectasia (CAE) is an abnormal dilatation of coronary arteries associated with ischemic comp lications and thrombotic events.Systemic inflammation and impaired nutritional status are believed to play a pivotal role in its pathogenesis.The Naples Prognostic Score (NPS), a composite marker of inflammation and nutrition, has been associated with adverse cardiovascular outcomes.This study aimed to evaluate the relationship between NPS and the presence of CAE.We retrospectively analyzed 139 patients who underwent coronary angiography between May 2023 and February 2026.Patients were classified into CAE (n=26) and control (n=113) groups.NPS was calculated based on serum albumin, total cholesterol, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR).Univariable and multiple logistic regression analyses were performed to identify predictors of CAE.Receiver operating characteristic (ROC) analysis assessed the discriminatory ability of NPS.Patients with CAE exhibited significantly higher NPS values compared to controls (2.15 ± 1.4 vs. 1.42 ± 0.9; p=0.025).Multiple analysis demonstrated that NPS was an independent predictor of CAE (OR: 2.018, 95% CI: 1.301 -3.129, p=0.002).ROC analysis revealed good discriminatory performance for NPS (AUC: 0.759, p<0.001).Higher NPS values are independently associated with the presence of CAE.NPS may serve as a simple, accessible biomarker reflecting systemic inflammation and malnutrition, providing additional risk strati fication in patients undergoing coronary evaluation.
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Şipal et al. (2026) conducted a case-control in Coronary artery ectasia (n=139). Naples Prognostic Score (NPS) vs. Control group without coronary artery ectasia was evaluated on Presence of coronary artery ectasia (CAE) (OR 2.018, 95% CI 1.301-3.129, p=0.002). Higher Naples Prognostic Score values were independently associated with the presence of coronary artery ectasia (OR 2.018, 95% CI 1.301–3.129, p=0.002) with an AUC of 0.759.
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