Key result
Elevated neutrophil-percentage-to-albumin ratio linked to ~2.1-fold higher odds of coronary artery ectasia.
Why the study?
Inflammation is believed to play a pivotal role in coronary artery ectasia, and the neutrophil-percentage-to-albumin ratio emerged as a novel inflammatory marker that may aid in its evaluation.
Does an elevated neutrophil-percentage-to-albumin ratio predict the presence and severity of coronary artery ectasia in patients undergoing elective coronary angiography?
Case-Control (n=345)
No
Does an elevated neutrophil-percentage-to-albumin ratio predict the presence and severity of coronary artery ectasia in patients undergoing elective coronary angiography?
Odds Ratio: 2.14
p-value: p=0.003
The neutrophil-percentage-to-albumin ratio is a readily available, cost-effective inflammatory biomarker that outperforms CRP in predicting both the presence and severity of coronary artery ectasia.
Background/Objectives: Coronary artery ectasia (CAE) is characterized by abnormal dilation of the coronary arteries and is associated with adverse cardiovascular events. Inflammation is believed to play a pivotal role in the development and progression of CAE. The neutrophil-percentage-to-albumin ratio (NPAR) has emerged as a novel marker of systemic inflammation and may serve as a useful tool in the evaluation of CAE. This study aimed to assess the association between the NPAR and CAE and compare its predictive value to established inflammatory biomarkers, including highly sensitive C-reactive protein (hsCRP), the neutrophil-to-lymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR). Methods: A retrospective analysis was conducted on 5212 patients who underwent elective coronary angiography between March 2019 and March 2023. The cohort included 165 patients with isolated CAE and 180 controls with normal coronary anatomy. Inflammatory markers and their correlation with CAE were analyzed using logistic regression models and receiver operating characteristic (ROC) analysis to determine predictive performance. Results: The NPAR was significantly elevated in the CAE group compared to the controls (p < 0.001). Multivariate analysis identified the NPAR (OR: 2.14, p = 0.003) and CRP (OR: 1.53, p = 0.02) as independent predictors of CAE. ROC analysis demonstrated that the NPAR had superior predictive value over CRP (AUC: 0.725 vs. 0.635). Additionally, the NPAR showed a strong correlation with CAE severity based on the Markis classification, with higher NPAR values associated with more advanced disease. Conclusions: The NPAR is an independent predictor of CAE and outperforms CRP in predicting both the presence and severity of the condition. As a cost-effective and accessible biomarker, the NPAR may enhance the clinical assessment of CAE and provide valuable insights into its inflammatory underpinnings. Further prospective studies are warranted to validate these findings and explore the potential of the NPAR in risk stratification and management of CAE patients.
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Karasu et al. (2025) conducted a case-control in Coronary artery ectasia (n=345). Neutrophil-Percentage-to-Albumin Ratio vs. Normal coronary anatomy was evaluated on Presence of isolated coronary artery ectasia (OR 2.14, p=0.003). An elevated neutrophil-percentage-to-albumin ratio independently predicted the presence of coronary artery ectasia (OR 2.14, p=0.003), outperforming CRP in diagnostic accuracy.
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