Case-control study evaluates NLR's diagnostic role in coronary artery ectasia, suggesting potential links to disease severity.
Background and Objective: Coronary artery ectasia (CAE), a diffuse or focal dilatation of coronary arteries, remains poorly understood. While the neutrophil-to-lymphocyte ratio (NLR) is a well-established infl ammatory marker in cardiovascular diseases, its diagnostic role in CAE is unclear. This study aimed to evaluate the diagnostic utility of NLR in CAE and explore its association with disease severity. Material and Methods: In this case-control study, 115 patients (28 CAE, 87 controls) admitted to Shahid Sadoughi Hospital (2012–2020) were analyzed. Demographic data, medical history, and complete blood count (CBC)-derived NLR were compared using SPSS and appropriate statistical tests. Results: The mean NLR did not differ signifi cantly between CAE (0.79 ± 2.01) and control groups (1.46 ± 2.07) (P = 0.830), nor by age, sex, or ectasia extent. However, NLR was lower in three-vessel involvement (0.49 ± 1.66) versus single-vessel involvement (1.04 ± 2.32) (P = 0.036). Conclusion: NLR lacks diagnostic value for CAE but may correlate with disease burden, as evidenced by reduced NLR in multi-vessel involvement. Further research should investigate NLR’s pathophysiological role and alternative infl ammatory markers in CAE.
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Nough et al. (2025) studied this question.
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