Key result
Coronary artery ectasia and CAD linked to higher neutrophil-lymphocyte ratio and mean platelet volume.
Why the study?
Inflammation markers may play a part in the pathogenesis of coronary artery ectasia, but their association with neutrophil-lymphocyte ratio was unclear.
Are elevated neutrophil-lymphocyte ratio and mean platelet volume associated with coronary artery ectasia compared to normal coronary angiograms?
Observational (n=181)
Are elevated neutrophil-lymphocyte ratio and mean platelet volume associated with coronary artery ectasia compared to normal coronary angiograms?
p-value: p=<.01
Elevated neutrophil-lymphocyte ratio and mean platelet volume are associated with coronary artery ectasia, suggesting a shared inflammatory pathophysiology with coronary artery disease.
May not alter CAE evaluation; leaves open shared inflammatory role with CAD for prospective studies.
Atherosclerosis plays an important role in the etiopathogenesis of coronary artery ectasia (CAE). Inflammation markers may play a part in the pathogenesis of CAE. We aimed to assess the association between the CAE and the neutrophil-lymphocyte (N/L) ratio. Consecutive eligible patients (n = 181) were divided into 3 groups: patients with CAE, those with newly diagnosed coronary artery disease (CAD), and those with a normal coronary angiogram. The N/L ratio and mean platelet volume (MPV) were measured as part of the automated complete blood count. There were no statistically significant differences in N/L ratio and MPV between the CAE and the CAD groups. The N/L ratio and MPV were significantly higher in patients in both CAE and CAD groups compared to those in the control group (P < .01). An increased N/L ratio may play a role not only in the pathogenesis of CAD but also in the pathophysiology of CAE.
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Balta et al. (2013) conducted an observational in Coronary artery ectasia (n=181). Coronary artery ectasia (CAE) and coronary artery disease (CAD) vs. Normal coronary angiogram was evaluated on Neutrophil-lymphocyte (N/L) ratio and mean platelet volume (MPV) (p=<.01). Neutrophil-lymphocyte ratio and mean platelet volume were significantly higher in patients with coronary artery ectasia and coronary artery disease compared to controls (P<.01).
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