MERP-DNA: A Computational and Genetic Bioinformatics Framework for Numerical Representation and Trajectory Analysis of DNA Sequences and Genomic Variants

This repository contains the MATLAB scripts, processed datasets, intermediate computational files, and experimental results associated with the research paper: "MERP-DNA: A Computational and Genetic Bioinformatics Framework for Numerical Representation and Trajectory Analysis of DNA Sequences and Genomic Variants." The deposited materials document the computational workflow developed and used in the study, including ClinVar data extraction, MANE reference integration, RefSeq sequence validation, coding-sequence identification, DNA sequence construction, MERP-DNA trajectory generation, mutation analysis, statistical evaluation, and visualization. The files are provided as supplementary research materials to support transparency, reproducibility, and independent examination of the computational procedures and results reported in the manuscript. The MATLAB scripts represent the computational implementation developed throughout the research process. Some scripts underwent modifications, corrections, refinements, and functional updates during the successive experimental stages. The deposited versions are intended to document the computational procedures associated with the reported study. Intermediate files are retained where relevant to document the progression of data processing and analysis.