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Background: Healthcare organizations increasingly require effective leadership, multidisciplinary coordination, patient safety management, and efficient resource utilization. Transformational healthcare leadership may improve outcomes by strengthening interprofessional collaboration. Objective: This study developed and examined an explanatory model linking Transformational Healthcare Leadership (THL), Interprofessional Collaboration (IPC), Patient Safety (PS), and Health Economic Outcomes (HEO) in selected multispecialty hospitals in Delhi NCR. Methods: A quantitative, cross-sectional, explanatory study was conducted with 628 healthcare professionals and managers. Structured questionnaires were used to assess THL, IPC, PS, and HEO. Data were analyzed using descriptive statistics, reliability testing, factor analysis, correlation, regression, structural equation modelling, and bootstrap mediation analysis. Results: THL was positively associated with IPC (β = .71, p < .001), and IPC was positively associated with PS (β = .53, p < .001). PS was positively associated with HEO (β = .58, p < .001), and THL was directly related to HEO (β = .22, p < .001). Significant indirect effects included the sequential pathway THL → IPC → PS → HEO (β = .218, 95% CI = .158–.284).
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